Artesunate/artesunate injection powder/88495-63-0 Artesunate factory
Basic Info
Model No.: PH-NJ-08
Product Description
Product Description Artesunate/artesunate injection powder/88495-63-0 Artesunate factory Appearance: Odorless bitter-tasting crystalline powder Extract Solent: Alcohol/water Artesunate: 98%-102%
Artesunate (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.
Synthesis
Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. Pyridine as base/solvent, sodium bicarbonate in chloroform and catalyst DMAP (N,N-dimethylaminopyridine) and triethylamine in 1,2-dichloroethane have been used, with yields of up to 100%. A large scale process involves treatment of DHA in dichloromethane with a mixture of pyridine, a catalytic amount of DMAP and succinic anhydride. The dichloromethane mixture is stirred for 6–9 h to get artesunate in quantitative yield. The product is further re-crystallized from dichloromethane. alpha-Artesunate is exclusively formed (m.p 135–137°C). The quality of our Artesunate?
Packaging & Shipping What is the packing? 
Can we provide sample? Yes, we can provide Artesunate sample for your testing before your purchasing. Contact us if you need more details on Artesunate. We are ready to answer your questions on packaging, logistics, certification or any Other aspects about Artesunate Price、Artesunate Injection. If these products fail to match your need, please contact us and we would like to provide relevant information.
Artesunate (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.
Synthesis
Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. Pyridine as base/solvent, sodium bicarbonate in chloroform and catalyst DMAP (N,N-dimethylaminopyridine) and triethylamine in 1,2-dichloroethane have been used, with yields of up to 100%. A large scale process involves treatment of DHA in dichloromethane with a mixture of pyridine, a catalytic amount of DMAP and succinic anhydride. The dichloromethane mixture is stirred for 6–9 h to get artesunate in quantitative yield. The product is further re-crystallized from dichloromethane. alpha-Artesunate is exclusively formed (m.p 135–137°C). The quality of our Artesunate?
ITEMS | SPECIFICATION | RESULTS |
CHARACTER | WHITE COLOR CREAM CRYSTALLINE POWDER | CONFORMS |
IDENTIFICATION | MUST POSITIVE | POSITIVE |
MELTING POINT | 129~140° | 132° |
SOLUBILITY | CONFORMS | CONFORMS |
COLOR OF SOUTION | CONFORMS | CONFORMS |
RELATED SUBSTANCES | CONFORMS | CONFORMS |
LOSS ON DRYING | NMT 0.5% | 0.32% |
ASSAY | NLT 99.0% | 99.13% |
CONCLUSION:CONFORM WITH THE REQUIREMENT OF ENTERPRISE. | ||
Can we provide sample? Yes, we can provide Artesunate sample for your testing before your purchasing. Contact us if you need more details on Artesunate. We are ready to answer your questions on packaging, logistics, certification or any Other aspects about Artesunate Price、Artesunate Injection. If these products fail to match your need, please contact us and we would like to provide relevant information. Product Categories : API > Antiparasitic
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