Model No.: CZG-S01
|Synonym||MK-677;Propanamide,2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,-4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy) methyl]ethyl]-2-methyl-,monomethanesulfonate;Ibutamoren mesylate [USAN];2-Amino-N-((R)-2-(benzyloxy)-1-((1-(methylsulfonyl)spiro(indoline-3,4-piperidin)-1-yl)carbonyl)ethyl)-2-methyl-propionamide monomethanesulfonate;MK-0677|
|Boiling Point||868.9°C at 760 mmHg|
|storage temp||Desiccate at RT|
Intermediates and Fine Chemicals;Pharmaceutical compounds;Inhibitor; Revatio
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|Biological Activity||Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC 50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro .|
|Usage||An orally active selective type 5 cGMP phosphodiesterase inhibitor. pharmaceutical material|
Ibutamoren Mesylate Description:
Nutrobal (Mk-677) is an orally administrated growth hormones secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormones. In other words, Nutrobal could be compared to Peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormones Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
Ibutamoren Mesylate Usage:
MK-677 is a medicine which acts as a potent, orally active growth hormones secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormones and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormones deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.
How to Work :
Growth hormones pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormones releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormones (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
|Characteristics||White to yellowish-white crystalline powder||conform|
|Melting point||32 ~ 37ºC||33~36ºC|
|Specific optical rotation||+77°~+82°||+79.3°|
|Loss on drying||≤0.5%||0.15%|
|Assay||97 ~ 103%||99.08%|
|Free heptanoic acid||≤0.2 %||0.10%|
|Residual solvents(GC)||Methanol ≤100ppm||Pass|
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